EFFECT OF AMOUNT OF HYDROPHOBIC LUBRICANT AND MIXING TIME ON PARACETAMOL TABLETS PROPERTIES

Authors

  • salam mohammad Tishreen University

Abstract

Magnesium stearate (Mg-St) is a widely used lubricant in solid drug formulations. In this research, we examined the effect of the lubricant magnesium stearate at various concentrations, mixing times, and mixers on granule flowability and paracetamol tablet properties (hardness, friability, disintegration time, and dissolution rate). It was found that increasing the mixing time of MgSt improved granule flow and reduced hardness statistically significantly, while increasing the MgSt concentration and the type of mixer did not have a statistically significant effect on the flowability and hardness. On the other hand, the disintegration time increases and the dissolution rate decreases statistically with increasing MgSt concentration and mixing time.

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Published

2023-07-25

How to Cite

1.
mohammad salam. EFFECT OF AMOUNT OF HYDROPHOBIC LUBRICANT AND MIXING TIME ON PARACETAMOL TABLETS PROPERTIES. Tuj-hlth [Internet]. 2023Jul.25 [cited 2025Jul.8];45(3):453-65. Available from: http://www.journal.tishreen.edu.sy/index.php/hlthscnc/article/view/14908

Issue

Vol. 45 No. 3 (2023): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Master student researches

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