العلاقة بين نقص البوتاسيوم المصلي والعلاج الإنشاقي بالسالبوتامول عند الأطفال أثناء النوبة الربوية
Abstract
أجريت هذه الدراسة لنقرر فيما إذا كان استخدام العلاج الإنشاقي بالسالبوتامول لعلاج النوبة الربوية عند الأطفال مرتبطاً مع نقص بوتاسيوم المصل. وفي حال كان كذلك فماهو تواتره وشدته ، وما هي الأعراض السريرية المرافقة. شملت عينة الدراسة 103 أطفال تراوحت أعمارهم بين 3سنوات و14 سنة مع نوبة ربوية حادة عولجوابـ 3 جرعات من السالبوتامول الإنشاقي 0.15ملغ /كغ كل عشرين دقيقة. تمت معايرة البوتاسيوم في المصل قبل وبعد الجرعات الثلاث من العلاج. انخفض متوسط مستوى البوتاسيوم المصلي من 3.94إلى 3.28 مك/ل(P < 0.05) . لوحظ انخفاض تركيز البوتاسيوم المصلي عند 93 طفلاً(90.3%). لوحظ نقص البوتاسيوم عند 71 طفلاً (69%).شكل نقص البوتاسيوم الخفيف النسبة الأعلى عند 43 طفلاً (41.7%) تلاه نقص البوتاسيوم المتوسط عند 28 طفلاً (27.2%)ولم يحدث نقص بوتاسيوم شديد .ترافق النقص مع أعراض سريرية (خفقان 23,ضعف عضلي 21,غثيان 15, صداع12 ,ألم عضلي 11, إقياء9) وكانت هذه الأعراض أكثر ارتباطاً بنقص البوتاسيوم المتوسط . This study was done to determine whether use of nebulized salbutamol therapy for treatment of an acute attack of asthma in children is associated with hypokalaemia and if so what is its frequency, severity and what is accompanying clinical symptoms 103 child, aged 3 years to 14 years with asthma attack, treated with three doses of nebulized salbutamol 0.15mg/kg, every 20 min participated in the study. Blood for serum potassium was obtained at the beginning and after three doses of nebulized salbutamol therapy.The mean serum potassium level decreased from 3.94 mEq/L to 3.28 mEq/L (P < 0.05). A decrease in serum potassium concentration was noted in 93 child (90.3%).). Mild hypokalemia formed the highest proportion in 43child (41.7%) followed by moderate hypokalemia in 28 child( 27.2%). Severe hypokalemia did not happen.This decrease was accompanied with clinical symptoms (palpitations 23,muscle weakness 21,nausea 15, headache 12,myalgia 11,vomiting 9).These symptoms were moreclosely to moderate hypokalemia.Downloads
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