The Role of Gabapentin in The Treatment of Tinnitus
Abstract
Tinnitus is considered one of the most common symptoms that urge the patient to visit the ENT doctors(otolaryngologists) it is also difficult to recognize exactly the main reason of tinnitus, which create a problem for the doctor and for the patient as well.
A research has been conducted on " 50" patients by using Gabapentin for treating tinnitus in patients visited private clinics and the ENT clinic in BaniasNathional Hospital during the period from 2012 to 2015.
Patients were given 200 mg Gabapentin orally every day, after ensuring their tolerance of Gabapentin, the dose was increased by average 200 mg every two weeks until it reached 1600 mg. The dose 1600mg was divided into two doses in the morning and in the evening. The treatment lasted for six months.
We observed, that Gabapentin had positive effects for treating tinnitus to the patients who didn't have acoustic trauma or long term noise. Treatment with Gabapentin was more effective on young people, and on who had a short term tinnitus .
Therefore,we conclude that the use of Gabapentin in treating tinnitus is advisable because of its major inhibitory neurotransmitter and its wide distribution in thecentral auditory pathway.
دور الغابابنتين Gabapentin في معالجة الطنين
يعتبر الطنين أحد أشيع الأعراض التي يأتي بها المرضى الى طبيب الاذن والانف والحنجرةوالتي غالبا يصعب معرفة السبب المؤدي لها وهذا يشكل مصدر قلق للمريض والطبيب .
تم اجراء البحث باستخدام عقار دوائي هو الغابابنتين في معالجة الطنين عند 50 مريضا من مراجعي العيادة الخاصة والعيادة الاذنية في الهيئة العامة لمشفى الشهيد اياد احمد ابراهيم ( بانياس الوطني سابقا) خلال الفترة
2012 م – 2015 م.تم اعطاء الغابابنتين بجرعة 200 ملغ يوميا فمويا, وبعد التأكد من التحمل الدوائي تم زيادة الجرعة بشكل تدريجي بمعدل 200ملغ كل اسبوعين, وبجرعة قصوي 1600 ملغ يومياً مقسمة على جرعتين صباحية ومسائية, واستمرت المعالجة لمدة ستة اشهر .
لوحظ وجود تأثيرات ايجابية في معالجة الطنين عند المرضى الذين لم يتعرضوا للرضوض الصوتية أو التأثير المديد للضجيج , وكانت الاستجابة للمعالجة افضل في الاعمار المبكرة وايضا كلما كانت الفترة الزمنية للطنين قصيرة, ولذا ينصح باستخدام الغابابنتين كدواء مثبط للنواقل العصبية في الطرق السمعية المركزية في معالجة الطنين.
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