Expression of B-catenin in Human Papilloma virus –Positive in Tonguesquamos Cell carcinoma. )An Immunohistochemistry study(
Abstract
High risk human Papilloma virus (Hpv) plays role as oncogen virus of cancer. This study describes changes in cell adhesion Molecules during tumor progression of HPv-related and unrelated Tongue carcinoma .
Methods and Result:
We examind 48 primary tumors of tongue carcinoma samples fortheir HPV status and B-catenin expression .
Appositive HPV polymerase chain reaction finding a correlation with nuculear B-catenin localization (p=0,03)
Conclusion:
Our study indicate that the nuclear translocation of B-cateninexpression might be crucial steps duringtumor progression of tongue carcinoma
تحري تعبيرية b-catenin في سرطان شائك الخلايا لقاعدة اللسان الايجابي والسلبي تبعا للاصابة ب الفيروس الحليمي البشروي (دراسة نسيجية مناعية )
تعتبر الفيروسات الحليمية البشروية من أخطر الفيروسات المسببة للاورام وخاصة العالية الخطورة منها . هذه الدراسة تصف التغيرات الجزيئية الحاصلة في جزيئات الربط في سرطان شائك الخلايا للسان وذلك من خلال سير الورم وتبعا لحالة HPV.
المواد والطرق :
تم دراسة 48 عينة من سرطان شائك الخلايا من أرشيف قسم النسج والتشريح المرضي للمرضى المراجعين لكلية طب الاسنان وتم توزيع العينات تبعا للاصابة ب HPV كما تم دراسةا التعبير النسيجي ل B-catenin ومقارنتها تبعا ل لحالة HPV التي تم تحديدها باستخدام تقنية PCR . تم ايجاد علاقة بين التوضع النووي ل B-catenin و ايجابية ال HPV (0,03).
الاستنتاج : دراستنا توضح ان التوضع النووي للb-catenin خلال مراحل الاصابة ب الفيروس قد يلعب دورا هاما في تطور الاورام البشروية للسان .
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