مقارنة بين الإيفيرميكتين الفموي والبيرميثرين الموضعي في معالجة الجرب
Abstract
شملت هذه الدراسة (105) مرضى مصابين بالجرب من مراجعي العيادة الخارجية في قسم الأمراض الجلدية في مستشفى الأسد الجامعي باللاذقية خلال الفترة الممتدة بين تموز2008 وتموز 2009 . وقد تم استبعاد الأطفال دون سن الخامسة, فضلاً عن الحوامل و المرضعات و المصابين بأمراض كلوية أو كبدية أو قلبية أو عصبية, فضلاً عن المرضى الذين استخدموا مضاد للجرب قبل أسبوع من الدراسة .
وتم تقسيم المرضى عشوائياً إلى مجموعتين: ضمت المجموعة الأولى 50 مريضا" عولجوا بالإيفيرميكتين الفموي إذ تم إعطاء الدواء كمضغوطة تحوي 6 ملغ وكجرعة كلية ( 200 مكغ \ كغم )حسب وزن جسم المريض. وضمت المجموعة الثانية 55 مريضا" عولجوا موضعيا" بدهون البيرميثرين 5% .
كما تم تصنيف شدة المرض حسب الاندفاعات إلى: خفيف (10 اندفاعات أو أقل ), متوسط (من 11-49 اندفاعاً) , شديد ( 50 اندفاعاً أو أكثر ) .
إن هدف هذه الدراسة تقدير فعالية الايفيرميكتين و تحديد درجة أمانه عند استخدامه في علاج الجرب الإنساني والمقارنة بين فعالية الإيفيرمكتين بجرعة فموية 200 مكغ/كغم والبيرميثرين 5%الموضعي .
This study included 105 scabietic patients attending the outpatient clinic of Al-assad University Hospital in Lattakia from July 2008 to July 2009. Children aged less than 5 years, patients who had received any antiscabietic treatment a week before this study was conducted, pregnant and lactating women, and patients with serious central nervous system, hepatic, cardiac, or renal diseases were excluded from this study. Patients chosen were divided into two groups. The first included 50 patients and was treated by oral ivermectin which was administered as scored 6-mg tablets, and the dose was designed to provide 200μg/kg. The second included 55 patients and was treated by topical permethrin 5%. The severity of disease was considered mild (10 or fewer lesions), moderate (11-49 lesions), or severe (50 lesions or more). The aim of the study was to determine the efficacy and safety of ivermectin and to compare the efficacy of a single oral dose of 200 μg/kg of body weight of ivermectin with a topical lotion of 5% permethrin in the treatment of human scabies.
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