Evaluate the Role and Efficacy of Intravenous Tranexamic Acid in Open Rhinoplasty and its Impact on Complications
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تجميل الأنف، حمض الترانكزاميك، النزفAbstract
Background: Over the past decade, individuals' aesthetic sensibilities have notably evolved, leading to rhinoplasty becoming one of the most prevalent cosmetic surgeries globally. Bleeding during and post-rhinoplasty is a frequent complication, prompting various preventive and therapeutic approaches to mitigate this issue. Among these, tranexamic acid (TXA) stands out as a significant hemostatic pharmacological agent.
Objective: This study aims to assess the efficacy of tranexamic acid in reducing complications, particularly bleeding, during rhinoplasty.
Materials and Methods: Following the necessary approvals, written consent was acquired from patients for participation in the study. Participants were randomly assigned to two groups: one undergoing rhinoplasty with tranexamic acid and the other with a placebo. An open surgical approach was employed for all patients. The first group received 10 mg/kg of tranexamic acid intravenously, while the second group received 10 ml of saline solution post-anesthesia. Bleeding was measured in milliliters, and pain relief was administered immediately before the surgical procedure concluded. Key outcomes included bleeding volume, pain assessed via the Visual Analogue Scale (VAS), and evaluations of periorbital bruising and edema. Surgical procedure outcomes and postoperative complications were documented, with results analyzed using SPSS Version 26.
Results: The sample comprised 64 patients, with a mean age of 28.5 ± 6.8 years. Males constituted 12.5% (8 patients) and females 87.5% (54 patients) of the sample. The Body Mass Index (BMI) averages were 23.9 ± 3.4 kg/m² for the first group and 24.6 ± 4.1 kg/m² for the second group.
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